Dendritic cell Flt3 – regulation, roles and repercussions for immunotherapy

KR Wilson; JA Villadangos; JD Mintern

Journal article

Dendritic cell Flt3 – regulation, roles and repercussions for immunotherapy

KR Wilson, JA Villadangos, JD Mintern

Immunology and Cell Biology | Published : 2021

DOI: 10.1111/imcb.12484

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Abstract

Dendritic cells (DCs) are essential for initiating immune responses. Depending on the environment, the type of DC and the way in which they interact with T cells, these immune responses can be beneficial or detrimental. DCs can be exploited as cellular vectors for vaccines against infection and cancer. The development and maintenance of DCs is dependent on the FMS-like tyrosine kinase 3 (Flt3)/Flt3 ligand (Flt3L) signaling cascade. Flt3 is also one of the most commonly mutated genes in acute myeloid leukemia and as such represents an attractive drug target. In this review, Flt3 is discussed with a particular focus on DCs. We detail the lifecycle of Flt3, from transcription to degradation, an..

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University of Melbourne Researchers

Kayla Wilson Author

Jose Villadangos Author

Justine Mintern Author

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Grants

Awarded by Human Frontier Science Program

Funding Acknowledgements

This work was supported by National Health and Medical Research Council, Department of Health Australia grants or fellowships (1058193, 1113293, 1154502 and 1163090 [to JAV], and 1161101 and 1129672 [to JDM]), Australian Research Council, Department of Education and Training grants or fellowships (160103134, 170102471, 190102213 [to JAV] and 190101242, 180100844, 160101373, and 180100521 [to JDM]), a Human Frontiers Science Program grant (0064/2011 [to JAV]), and the Victorian State Government Operational Infrastructure Support and the Independent Research Institutes Infrastructure Support Scheme of the Australian Government National Health and Medical Research Council.